One of those renovations, the Scale Up Laboratory, required the reconfiguration of adjacent laboratory spaces to support a larger, more unified lab housing process development operations and equipment including bioreactors, centrifuges, chromatography skids, buffer and media preparation and storage and filtration operations. To achieve this, Consigli managed the structural demolition and reconfiguration of the space; installation of condenser pads; tie-ins and redistribution of existing M/E/Ps; and the installation of new finishes, flooring and casework. Additionally, existing instrument air, carbon dioxide, oxygen, nitrogen, process vent, chilled water, RODI and clean steam process systems were redistributed, and stainless steel process waste headers were installed. All work was completed within an occupied laboratory building, including immediately adjacent to occupied offices and research labs, requiring carefully coordinated shutdowns and project coordination.

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All construction activities were managed within this active laboratory research and manufacturing environment, requiring stringent coordination, communication and safety measures to avoid interruptions to occupant activities. The construction zone was located adjacent to active laboratories, requiring a detailed indoor air quality plan and procedures to control particle transfer between construction and non-construction zones.

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Additionally, the project included the installation of a mist booth, bioreactor, biosafety cabinet, and isolator. In order to support the new equipment, several new validated & non-validated utilities, such as clean steam, glycol, nitrogen and IA/PA, were piped to panels in the room. Structural modifications were completed to create an ISO 5 airlocks with a purposeful flow of equipment and personnel into the Suite.

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To achieve this, Consigli managed the structural demolition and reconfiguration of the space; installation of condenser pads; tie-ins and redistribution of existing M/E/Ps; and the installation of new finishes, flooring and casework. Additionally, existing instrument air, carbon dioxide, oxygen, nitrogen, process vent, chilled water, RODI and clean steam process systems were redistributed, and stainless steel process waste headers were installed. All work was completed within an occupied laboratory building, including immediately adjacent to occupied offices and research labs, requiring carefully coordinated shutdowns and project coordination.

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Developed to house Biogen’s general and administrative functions, the building includes flexible and innovative spaces to encourage collaboration. Other amenities include a conference center, 6,300 sq. ft. cafeteria and community laboratory. The 305,000 sq. ft. office building also has 105,000 sq. ft. of below-grade parking. The modern architecture of the six-story building, featuring a glass and terra-cotta façade, has incorporated two existing historic buildings.

The building’s co-located and integrated design, engineering and subconsultant teams perform work through design-assist and utilized BIM extensively. Project achieved LEED Gold certification.

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The first phase included site infrastructure development and the construction of the 25,600 sq. ft. Walter and Helen Norton Center for Blue Biotechnology, which houses the first microbial single-cell genomics facility and largest collection of marine phytoplankton in the world.

The second phase included the 17,197 sq. ft. Center for Ocean Biogeochemistry and Climate Change, a laboratory for research on the role of plankton in climate change. The final phase involved the 16,600 sq. ft. Bigelow Center for Ocean Health, which provides laboratories for research on marine microbial ecosystems and their role in maintaining the health of the oceans. The facility is augmented by a 1,400 sq. ft. shore facility, with pier and dock space for research vessels.

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Biogen’s new headquarters includes an open, non-hierarchical office space and “huddle rooms” to enhance information sharing and collaboration, a conference center, satellite cafés and a 225-seat, 6,300 sq. ft. cafeteria and dining area that serves the entire Biogen campus.

Our team managed the tenant fit-out concurrently with the 453,164 sq. ft. base building construction, designed by a separate architect. Co-location and design-assist were utilized to ensure a cohesively designed, coordinated and constructed finish space.

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The project was managed on an aggressive schedule to meet lease agreements and also attract additional tenants. The core and shell upgrades for this building included extensive M/E/P infrastructure with the capacity for multiple research tenants, including installation of a new mechanical penthouse, as well as complete HVAC and sprinkler upgrades. The exterior scope included significant exterior masonry restoration and the installation of all new windows. Interior work included the installation of new laboratory casework, fume hoods along with new doors and hardware throughout.

The second phase of the project included the full fit-out for two clients, Sun Catalytix and Epizyme. Completed on aggressive schedules, the fit-out involved installation of fume hoods, lab sinks, snorkels and associated HVAC upgrades. The project also included the installation of office spaces with movable partitions to provide flexibility.

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Breakthrough Properties, a life science real estate development company, launched by Tishman Speyer and Bellco Capital, acquired its first development site at 105 West First Street in Boston’s Seaport District. The new construction, located on a one-acre site, is an eight-story life science research and development. Building amenities include a below-grade fitness center, covered parking for 35 spaces, ground-floor retail, and communal wet labs and innovation and technology incubator space.

The project’s scope included the demolition of an existing 1980’s two-story structure and grading of the sloping site with a unique 15-foot elevation variance from one side to the other. Complex site conditions dictate the use of drilled H-piles and lagging along the perimeter with an internal raker system to allow for one-sided walls and spread footings at the perimeter and core areas. The steel building’s façade was procured with a design-assist contract and is comprised of a unitized VisionGlass and terracotta wall system. Interior fit-out work for the core/shell construction was limited to the building common areas and amenity spaces with the majority of the floors prepped with all necessary infrastructure to accommodate future life science tenants.

The building achieved LEED Gold v4 Core and Shell certification and  incorporates strategies outlined by the City of Boston’s Climate Change Preparedness and Resiliency guidelines and was built with a flood preparedness plan.

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Bristol-Myers Squibb (BMS) is reorganizing its Biologics Department capabilities by consolidating multi-site operations to a singular location in Devens, MA. The existing Biologics Development Building (BDB) hosts occupied laboratory, research, manufacturing and office space on the first and second floors; all fit-out activities associated with this project occured within shell space on the third floor.

The reconfigured third floor houses new laboratories, cold rooms and collaboration and office space for approximately 120 personnel within BMS’ Quality Control, Analytical Science & Technology, Manufacturing Sciences & Technology and Biologics Departments. The new laboratory configurations tie-in to the existing building and campus infrastructure, resulting in invasive coring activities that will stretch to other floors within the occupied BDB. These tie-ins require full validation and testing of the systems to eliminate opportunities for contamination. Our team developed and execute work plans for each activity, coordinate shutdowns and work during off-hours shifts to mitigate construction disruptions. The third floor windows were removed for building access and pre-fabricated elements were incorporated to achieve efficient mechanical installation sequences.

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